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hxlA [2019-07-22 10:59:37]
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hxlA [2019-07-22 10:59:37]

3-hexulose-6-phosphate synthase
Locus
BSU_03460
Isoelectric point
4.56
Molecular weight
22.43 kDa
Protein length
210 aa Sequence Blast
Gene length
633 bp Sequence Blast
Function
ribulose monophosphate pathway for formaldehyde fixation
Product
3-hexulose-6-phosphate synthase
Essential
no
E.C.
4.1.2.43
Synonyms
yckG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

    • Gene

    Coordinates
    375,166 → 375,798

    The protein

    Catalyzed reaction/ biological activity

  • D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde (according to Swiss-Prot)

    • Protein family

  • HPS/KGPDC family (single member, according to UniProt)

    • Structure

  • 3F4W (from Salmonella typhimurium, 44% identity)

    • Expression and Regulation

    Operons

    Genes
    hxlA-hxlB
    Description
    PubMed

    Regulatory mechanism

  • HxlR: activation, PubMed, in HxlR regulon

    • Regulation

  • induction by formaldehyde (HxlR) PubMed
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    Biological materials

    Mutant

  • MGNA-C057 (yckG::erm), available at the NBRP B. subtilis, Japan
  • BKE03460 (ΔhxlA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTTGATCCACTCCCTT, downstream forward: _UP4_CTGATTGTCCAAGGATAACT
  • BKK03460 (ΔhxlA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTTGATCCACTCCCTT, downstream forward: _UP4_CTGATTGTCCAAGGATAACT

    • References

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